Correlation of ultrastructural changes of endothelial cells and astrocytes occuring during blood brain barrier damage after traumatic brain injury with biochemical markers of BBB leakage and inflammatory response
نویسندگان
چکیده
1 Department of Clinical Biochemistry and Pathobiochemistry, Charles University 2 Medical School and University Hospital Motol, Prague. 2 Institute of Microbiology, v.v.i. Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20 Prague. 3 Department of Forensic Medicine and Toxicology, Charles University 1 Medical School , Prague. 4 Neurosurgery Department, Charles University 3 Medical School, Prague. 5 Department of Forensic Medicine, Charles University 2 Medical School , Prague 6 Department of Chemistry and Biochemistry, Mendel University of Agriculture and Forestry, Zemedelska 1, 613 00, Brno
منابع مشابه
Correlation of Ultrastructural Changes of Endothelial Cells and Astrocytes Occurring during Blood Brain Barrier Damage after Traumatic Brain Injury with Biochemical Markers of Blood Brain Barrier Leakage and Inflammatory Response
D. VAJTR, O. BENADA, J. KUKAČKA, R. PRŮŠA, L. HOUŠŤAVA, P. TOUPALÍK, R. KIZEK Department of Clinical Biochemistry and Pathobiochemistry, Charles University 2 Faculty of Medicine and University Hospital Motol, Prague, Institute of Microbiology, v.v.i. Academy of Sciences of the Czech Republic, Prague, Department of Forensic Medicine and Toxicology, Charles University 1 Faculty of Medicine, Pragu...
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Traumatic brain injury (TBI) is defined as an external mechanical injury to the brain. Neuroinflammation plays a vital role in the pathophysiology of TBI. Microglia and astrocytes play a central role in the initiation and regulation of inflammation. Numerous pro-inflammatory mediators including cytokines, chemokines, reactive oxygen species (ROS) and nitric oxide (NO) released by microglia. In ...
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